Activity-dependent differences in function between proximal and distal Schaffer collaterals
نویسندگان
چکیده
منابع مشابه
Activity-dependent differences in function between proximal and distal Schaffer collaterals.
Axon conduction fidelity is important for signal transmission and has been studied in various axons, including the Schaffer collateral axons of the hippocampus. Previously, we reported that high-frequency stimulation (HFS) depresses Schaffer collateral excitability when assessed by whole-cell recordings from CA3 pyramidal cells but induces biphasic excitability changes (increase followed by dec...
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Previous studies established different responses between proximal and distal portions of Schaffer collateral axons during high-frequency and burst stimulation, with distal axons demonstrating biphasic changes in excitability (hyperexcitability followed by depression), but proximal axons showing only monophasic depression. Voltage-dependent potassium (KV) channels are important determinants of a...
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Hippocampal region CA1 seems from comparative studies to be particularly important in the primate brain, in addition to being crucial to memory function. Thus, it is an extremely appropriate place to begin a quantitative investigation of the information representation and transmission capabilities of cerebral neural networks. In this study, a mathematical model of the Schaffer collateral projec...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2015
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00446.2014